Deciphering the evolution and metabolism of an anammox bacterium from a community genome
- Author(s)
- Marc Strous, Eric Pelletier, Sophie Mangenot, Thomas Rattei, Angelika Lehner, Michael W Taylor, Matthias Horn, Holger Daims, Delphine Bartol-Mavel, Patrik Wincker, Valerie Barbe, Nuria Fonknechten, David Vallenet, Beatrice Segurens, Chantal Schenowitz-Truong, Claudine Medigue, Astrid Horn, Berend Snel, Bas E. Dutilh, Huub J. M. Op Den Camp, Chris D. Van Der Drift, Irina Cirpus, Katinka T. van de Pas-Schoonen, Harry R. Harhangi, Laura Van Niftrik, Markus C. Schmid, Jan T.M. Keltjens, Jack van de Vossenberg, Boran Kartal, Harald Meier, Dmitrij I. Frishman, Martin A. Huynen, Hans Werner Mewes, Jean S. Weissenbach, Mike S. M. Jetten, Michael Wagner, Denis L. Le Paslier
- Abstract
Anaerobic ammonium oxidation (anammox) has become a main focus in oceanography and wastewater treatment1,2. It is also the nitrogen cycle's major remaining biochemical enigma. Among its features, the occurrence of hydrazine as a free intermediate of catabolism3,4, the biosynthesis of ladderane lipids5,6 and the role of cytoplasm differentiation7 are unique in biology. Here we use environmental genomics8,9 - the reconstruction of genomic data directly from the environment - to assemble the genome of the uncultured anammox bacterium Kuenenia stuttgartiensis10 from a complex bioreactor community. The genome data illuminate the evolutionary history of the Planctomycetes and allow us to expose the genetic blueprint of the organism's special properties. Most significantly, we identified candidate genes responsible for ladderane biosynthesis and biological hydrazine metabolism, and discovered unexpected metabolic versatility. Π2006 Nature Publishing Group.
- Organisation(s)
- External organisation(s)
- Radboud University, Centre National De La Recherche Scientifique (CNRS), Universität Zürich (UZH), University of Auckland, UPR Amelioration Genetique d' Especes a Multiplication Vegetative, Utrecht University, Delft University of Technology, Technische Universität München
- Journal
- Nature
- Volume
- 440
- Pages
- 790-794
- No. of pages
- 5
- ISSN
- 0028-0836
- DOI
- https://doi.org/10.1038/nature04647
- Publication date
- 2006
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 106022 Microbiology
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/16c4d45f-f0bd-4844-8e05-f60244d5b0f2