The Fish Pathogen "Candidatus Clavichlamydia salmonicola"-A Missing Link in the Evolution of Chlamydial Pathogens of Humans

Author(s)
Astrid Collingro, Stephan Köstlbacher, Alexander Siegl, Elena R Toenshoff, Frederik Schulz, Susan O Mitchell, Thomas Weinmaier, Thomas Rattei, Duncan J Colquhoun, Matthias Horn
Abstract

Chlamydiae like Chlamydia trachomatis and Chlamydia psittaci are well-known human and animal pathogens. Yet, the chlamydiae are a much larger group of evolutionary ancient obligate intracellular bacteria that includes predominantly symbionts of protists and diverse animals. This makes them ideal model organisms to study evolutionary transitions from symbionts in microbial eukaryotes to pathogens of humans. To this end, comparative genome analysis has served as an important tool. Genome sequence data for many chlamydial lineages are, however, still lacking, hampering our understanding of their evolutionary history. Here, we determined the first high-quality draft genome sequence of the fish pathogen "Candidatus Clavichlamydia salmonicola", representing a separate genus within the human and animal pathogenic Chlamydiaceae. The "Ca. Clavichlamydia salmonicola" genome harbors genes that so far have been exclusively found in Chlamydia species suggesting that basic mechanisms important for the interaction with chordate hosts have evolved stepwise in the history of chlamydiae. Thus, the genome sequence of "Ca. Clavichlamydia salmonicola" allows to constrain candidate genes to further understand the evolution of chlamydial virulence mechanisms required to infect mammals.

Organisation(s)
Department of Microbiology and Ecosystem Science
External organisation(s)
Wageningen University and Research Centre, Eidgenössische Technische Hochschule Zürich, United States Department of Energy, FishVet Group Ireland, Oranmore, Co., University of Bergen (UiB)
Journal
Genome Biology and Evolution
Volume
15
No. of pages
12
ISSN
1759-6653
DOI
https://doi.org/10.1093/gbe/evad147
Publication date
08-2023
Peer reviewed
Yes
Austrian Fields of Science 2012
106026 Ecosystem research, 106022 Microbiology
Keywords
ASJC Scopus subject areas
Medicine(all)
Portal url
https://ucrisportal.univie.ac.at/en/publications/the-fish-pathogen-candidatus-clavichlamydia-salmonicolaa-missing-link-in-the-evolution-of-chlamydial-pathogens-of-humans(2c308e31-444f-40e8-bb78-c54abad10424).html