These obligate intracellular bacteria have evolved the ability to infect and establish symbiotic associations with amoebae independently and thus represent ideal model systems to investigate the diversity and evolution of the intracellular life style and underlying mechanisms for host-interaction.
We use a comprehensive, polyphasic approach including the complete array of omics technologies, biochemical characterization of key proteins, phylogenetic and evolutionary analysis to study amobae-associated symbionts. We have been focusing on chlamydial symbionts for over a decade, but we are also investigating the Bacteroidetes symbiont Amoebophilus asiaticus, the rickettsial symbiont Jidaibacter acanthamoeba, and the betaproteobacterial symbiont Procabacter.
Infection strategies used by extant bacterial pathogens have been developed during primordial interactions with unicellular eukaryotes, such as amoebae, as “evolutionary training ground”. The analysis of modern amoeba symbionts therefore also contributes to a better understanding of the evolution of pathogenicity and the emergence of bacterial pathogens.
Investigated by: