BiOcean5D: Marine biodiversity assessment and prediction across spatial, temporal and human scales

BiOcean5D is a major interdisciplinary project designed to better understand the impact of human activity on Europe's seas and coastlines.
☎ +43 1 4277 91203
✉ elizabeth.hambleton(at)univie.ac.at
» CV
» u:cris
» u:find

» Full publications list
» Google Scholar
Liz Hambleton’s group studies the evolution and molecular mechanisms of diverse, ecologically important photosynthetic symbioses (“photosymbioses”) between symbiotic dinoflagellate algae and marine invertebrates. Her main research questions include: how do different host organisms interact on the cellular level with the same intracellular algal symbiont? What are the molecular mechanisms underlying these symbioses, particularly metabolic exchange? Liz’s group combines functional experimentation in model systems, single-cell transcriptomics, metabolomics, and mass spectrometry-based metabolic imaging. Throughout her career, Liz has been an expert in studying molecular mechanisms of coral-algal symbiosis, including the exchange of essential sterol nutrients. In addition, her group is also establishing a new model system with symbiotic acoel flatworms. The group’s ultimate aim is to understand globally widespread and evolutionarily important photosymbioses and their responses to environmental change.
We predominantly conduct laboratory experiments using our animal and algae cultures in the AquaLab at UBB, University of Vienna. Some projects also involve fieldwork in the Mediterranean and Japan.
The photosymbiotic organisms we are currently focusing on are cnidarians and acoel flatworms. We have multiple lines of the model sea anemone Aiptasia sp. in the lab, and we conduct fieldwork on Acropora sp. reef-building corals and Anemonia sp. temperate anemones. We have also established a new molecular model system with the acoel flatworm Waminoa sp. In the wild, these flatworms live epizoically on coral surfaces yet have a distinct stable symbiosis with algae. We have multiple clonal lines of symbiotic adults, and have generated aposymbiotic worms. The Waminoa grow happily in AquaLab in Ikea glassware and divide both asexually and sexually. The naturally aposymbiotic juvenile worms grow and take up symbiotic algae from the environment, giving us the opportunity to synthetically reconstitute symbiosis with defined partners.
PhD Student
Jacobovitz MR, Hambleton EA, Guse A. Unlocking the Complex Cell Biology of Coral-Dinoflagellate Symbiosis: A Model Systems Approach. Annual Review of Genetics. 2023 Nov 27;57:411-434. doi: 10.1146/annurev-genet-072320-125436
Maegele I, Rupp S, Özbek S, Guse A, Hambleton EA, Holstein TW. A predatory gastrula leads to symbiosis-independent settlement in Aiptasia. Proceedings of the National Academy of Sciences of the United States of America. 2023 Sept 25;120(40):e2311872120. doi: 10.1073/pnas.2311872120
Hambleton EA. How corals get their nutrients. eLife. 2023 Aug 18;12:e90916. doi: 10.7554/eLife.90916
Gornik SG, Maegele I, Hambleton EA, Voss PA, Waller RF, Guse A. Nuclear transformation of a dinoflagellate symbiont of corals. Frontiers in Marine Science . 2022 Nov 9;9:1035413. doi: 10.3389/fmars.2022.1035413
Bien T, Hambleton EA, Dreisewerd K, Soltwisch J. Molecular insights into symbiosis-mapping sterols in a marine flatworm-algae-system using high spatial resolution MALDI-2-MS imaging with ion mobility separation. Analytical and Bioanalytical Chemistry. 2021 Apr;413(10):2767–2777. Epub 2020 Dec 3. doi: 10.1007/s00216-020-03070-0